Inhibition of soluble TNFa using a dominant-negative strategy effectively promotes RGC survival.

Retinas were obtained and processed for RGC counting with a confocal microscope.

Caspase-2-dependent cell death is important and evidenced in models of RGC degeneration.

Conclusion: The elevation in IOP precedes the loss of RGCs by several months.

RGCs cell loss occurs particularly in peripheral regions of the retina.

The effect of hrDecorin treatment on RGC survival was also assessed.

Here we find TRPV1 localized in monkey and human RGCs, similar to rodents.

Expression increases in RGCs exposed to acute changes in pressure.

RGC function was evaluated by recording positive scotopic threshold response.

In conclusion, different RGC types use diverse mechanisms to produce sustained or transient light responses.

However, the TGF-β mechanism of protective effects against oxidative stress damage in RGCs still undetermined.

Cre-expressing RGCs lacked GABA labeling and included classically defined as well as recently identified types.

The immunological profile of RGC patients suggests that they would be good candidates for immunotherapy.

These RGCs encode NBS-LRR resistance-like proteins that are closely similar to the tomato I2 R-protein.

The amount of IOP elevation and RGC loss correspond with the number of laser burns applied.

This later time point is associated with development of dendritic abnormalities and irreversible death of RGCs.